WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF FLOATING TABLETS OF GABAPENTIN

Abhijit Satpathy*, K. C. Panigrahi, Soumyastuti Patnaik and Ch. Niranjan Patra

ABSTRACT

Gabapentin is used as anticonvulsant drug belongs to BCS class III. It has high aqueous solubility and less permeability. It exhibits low oral bioavailability i.e. 27% only. The primary objective of the present research was to improve the gastric residence time and bioavailability of gabapentin using different polymer HPMC K 100M and HPMC K4M and also to study the effect of various excipients on the solubility and rate of dissolution as secondary objective. The FTIR study of the optimized formulation, blank physical mixture and drug loaded physical mixture revealed no interaction with drug and polymer. The DSC study of the formulation and physical mixture also confirmed there was no any interaction with drug and polymer. The floating tablets of drug was prepared using HPMC K100M and HPMC K4M as polymer and other excipients in different drug, polymer and excipients ratios by direct compression method. The flow properties of formulation found to be better as compared to the drug alone and also to the physical mixture. In vitro dissolution study of all formulations were carried out using USP II apparatus and found formulation F5 has better dissolution rate and solubility as compared to other formulations.

Keywords: Gabapentin, HPMC K100M, HPMC K4M, direct compression.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More