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Abstract

AN UPDATED REVIEW OF CYCLODEXTRIN

Ananya Kumari Aich*, Sradhanjali Patra, Parimita Sahu, Bhagyashree Patra

ABSTRACT

Cylodextrins [CD] are family of oligosaccharides bound together in a single ring. There are 3 types of cyclodextrins these are α-c, α-CD[6- membered sugar ring],β-CD[7-membered sugar ring] and γ-CD[8- membered sugar ring].β –CD has 2 derivatives these are hydroxyl propyl –beta-cyclodextrin [HPβCD] and carboxy methyl-beta cyclodextrin[CMβCD]. Comparision of the capacity of β-CD derivatives and cyclophanes to shuttle cholesterol between cells & serum liproprotin. Cyclodextrins are non-hygroscopic, white, odourless, fine crystalline powder having a slight sweet taste. The most important key differences in physical properties between 3 cyclodextrin is their water solubility and α–CD is most commonly used CD although it is least stable and β-CD was found to impact better stability to various drugs.

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