WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

APTAMER: A MIRACLE TOOL FOR TARGETED DRUG DELIVERY

Asutosh Parhi* and Manoj Panda

ABSTRACT

Aptamers are oligonucleotides (ss-RNA or DNA) having high affinity and specificity in identifying the target molecules, by folding into 3-D structures. They are identified from an initial library containing 1013 - 1016 random ssDNA or ssRNA sequences through an in vitro selection process termed SELEX (systematic evolution of ligands by exponential enrichment). Aptamers are different from antibodies, Aptamers are having novel properties, such as highly selective and specific target recognition and binding. Aptamers have advantages on antibodies like such as easier and more economical to produce; compared to antibodies, toxicity and low immunogenicity of particular antigens do not interfere with the aptamer selection; having greater specificity and affinity; can easiy be modified chemically to yield improved, custom tailored properties, much more stable at ambient temperature. These properties make aptamers ideal candidates for use in molecular medicine to cure of diseases, particularly cancer and infectious diseases.

Keywords: .


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More