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Abstract

ADAPTOGENIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF TRIPHALA IN ALBINO RATS

Diptimayee Jena*, Sambhunath Saha, Bimalendu Chowdhury, M. E. Bhanoji Rao

ABSTRACT

The present study was designed to perform the adaptogenic activity of hydroalcoholic extract of Triphala fruit (HAETF) part. The adaptogenic activity was evaluated by administering acute and chronic dose of HAETF in albino rats. The rats were randomly divided into five groups. Group one was not subjected to stress and were kept as normal control, group two was subjected to stress and were kept as stress control and other groups were treated with different dose of HAETF i.e. 100, 200 and 400 mg/kg p.o. and the adaptogenic activity was studied on acute swim endurance stress model and chronic swim endurance stress model for acute and chronic study respectively. In acute stress models, VMA level of the stress control rat was 21.42±1.49μg/ml and the normal control showed a VMA level of 3.92±1.39μg/ml which was statistically significant(p<0.01). The rats treated with 400mg/kg of HAETF showed VMA level 6.26±1.33μg/ml which showed no significant difference as compared to normal control. In chronic stress model rats were divided into three groups i.e. normal control, stress control and test group administered with 400mg/kg of HAETF and stress was applied by force swimming endurance test for eight days. On 8th day SGOT and brain MDA level was estimated. In case of stress control plasma SGOT and brain MDA level was significantly (p<0.001) increased. After treatment with HAETF at a dose of 400mg/kg all the parameters were reduced to normal. From this study it was concluded that, HAETF shows a significant adaptogenic activity in albino rats.

Keywords: VMA, plasma SGOT, brain MDA, force swim endurance stress model.


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