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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

IN VIVO AND IN VITRO ANTITUMOR ACTIVITY OF A NOVEL PH ACTIVATED POLYMERIC DRUG DELIVERY SYSTEM FOR DOXORUBICIN

Jyoshna Rani Dash*, Bandana Behera, Debasish Pradhan

ABSTRACT

Introduction: Conventional chemotherapy agent together with Doxorubicin (dox) is of limited clinical use because of its inherently low selectivity, that could lead to systemic toxicity in regular healthy tissue. Methods: A pH stimuli-sensitive conjugate based on polyethylene glycol (PEG) with covalently attachment doxorubicin through hydrazone bond (peg-hyd-dox) changed into organized for tumor focused on delivery gadget. while peg-dox conjugates thru amid bond (peg-ami-dox) turned into synthesized as control. Results: The artificial conjugates were confirmed by using proton nuclear magnetic resonance (nmr) spectroscopy, the release profile of dox from peg-hyd dox turned into acidchargeable for the hydrazone linkage between dox and peg, brought about one-of-a-kind intracellular uptake direction; intracellular accumulation of peg-hyd-dox became higher than peg-ami-dox because of its ph-brought about profile, and thereby more cytotoxicity towards mcf-7, mda-mb-231 (breast most cancers models) and hepg2 (hepatocellular carcinoma model) mobile lines. following the in vitro outcomes, we xenografted mda-mb-231 mobile onto scid mice, peg-hyd-dox confirmed stronger antitumor efficacy than loose dox and became tumor-targeting. Conclusions: effects from those in vivo experiments were regular with our in vitro effects; cautioned this ph-precipitated peg-hyd-dox conjugate may want to target dox to tumor tissues and launch unfastened tablets by means of acidic tumor surroundings, which would be potent in antitumor drug delivery.

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