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Abstract

PREPARATION METHODS FOR NANOPARTICLE: A SMART CARRIER SYSTEM FOR TREATMENT OF CANCER

Manisha Sahu*, Trilochan Satapathy, Sanjib Bahadur, Suman Saha, Prerna Purabiya,
Suruj Kaushik, Ashish Kumar Netam and Jhakeshwar Prasad

ABSTRACT

Novel approaches of drug delivery such as formulating the polymeric nanoparticles is revolutionizing the future of medicines. However there are several methods to prepare polymeric nanoformulation such as thin film hydration, Solid dispersion, Emulsion polymerization, Fessi method, emulsion-diffusion-evaporation method, interfacial polymerization method, Microemulsion, Fatty acid coacervation technique, High pressure emulsification-solvent evaporation technique. But the selection of a suitable method is a real concern, as the selection of inappropriate method may lead to loss of material resources, financial resources and time of research. Newly potent and target specific formulation led to enhance therapeutic utility. These challenges, coupled with the complexity and variety, are fueling the advancement of novel drug delivery systems that overcome bioavailability and delivery obstacles. In present scenario, nanoparticles have been acting as carriers for delivering a wide range of potential drugs. Due to their versatility and wide range of properties and they represent a promising drug delivery system of controlled and targeted release.

Keywords: Polymeric nanoparticles, bioavailability, preparation methods for nanoparticles, therapeutic utility.


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