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Abstract

ATTENUATION OF MONOSODIUM GLUTAMATE INDUCED NEUROTOXICITY BY HYDROALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA ROOTS IN ALBINO RATS

Pratishya Bhatta*, Binayaka Sethi, Bimalendu Chowdhury and M. E. Bhanoji Rao

ABSTRACT

The flavor enhancer monosodium glutamate (MSG) is a sodium salt of non-essential aminoacid glutamic acid. Because of flavor enhancing properties glutamate is deliberately added in food as purified monosodium salt. Many studies have reported that excess consumption of MSG produces neurotoxicity. The present study was designed on attenuation of MSG induced neurotoxicity by hydroalcohholic extract of Glycyrrhiza glabra (HAEGG) roots in albino rats. The rats were randomly divided into six groups. Group one was administered with 10ml/kg of distilled water p.o. and considered as negative control. Group two was administered with MSG, 2g/kg p.o.is considered as positive control. Group three was administered with MSG with Vitamin C, 100mg/kg p.o. and considered as standard. Group four, five and six were administered with MSG and 300, 400 and 600mg/kg of HAEGG p.o. respectively. The neurobehavioural study was performed by conducting locomotor activity using actophotometer, Memory impairment in light and dark chamber and anxiolytic activity in light and dark chamber. The rats treated with MSG showed a significant (p<0.01) decrease in locomotor activity as compared to vehicle treated group but after treatment with HAEGG the locomotor activity was increased dose dependently and significantly (P<0.01) as compared to MSG treated group. The values are also comparable with standard group. In light and dark model of memory retention test it has been observed that in case of MSG treated rat there was a significant (p<0.01) decrease in memory impairment was observed after 24 hrs, where as in case of HAEGG treated rats it shows a significant (p<0.01) increase in memory retention observed at a dose of 400 and 600 mg/kg which was comparable with standard. In case of anxiolytic activity the dark chamber latency was significantly (p<0.5) increased as compared to vehicle treated group, whereas HAEGG shows a significant (p<0.01) decrease in dark chamber latency observed at 600mg/kg and was comparable with standard drug. From this study it was concluded that HAEGG attenuates the MSG induced neurotoxicity.

Keywords: Locomotor activity using actophotometer, memory impairment and anxiolytic activity in light and dark chamber.


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