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Abstract

STANDARDIZATION AND AUTHENTICATION OF SEEDS OF AJMODA (APIUM GRAVEOLENS): THE DRUG ASSESSED FOR CHEMO PREVENTIVE ACTIVITY

Sagarika Parida*, Kedar Kumar Rout, Gyanranjan Mahalik, Nabin Kumar Dhal, Kunja Bihari Satpathy

ABSTRACT

India is endowed with a rich wealth of medicinal plants. A number of plant extracts are used against diseases in various systems of medicine such as Ayurveda, Siddha and Unani, popularly known as Indian System of Medicine (ISM) which have been widely practiced due to its efficacy and believed to be free off side effects. Literature data revealed that search for anticancer drugs from plant sources started in earliest in the 1950s and Apium graveolens seeds have been assessed for chemopreventive activity. Chemopreveventive includes use of synthetic or natural agents alone or in combination to block the development of cancer in human beings leading to cancer prevention. It is also revealed that A. graveolens have many pharmacological properties like anticonvalscent, tranquilizing, hypolipidemic, antifungal activities, anticancer and many more. The seeds are also used in bronchitis, asthma, spleen and liver disorders. This has increased the demand for plant raw materials with the result that a large number of traders connected with big industrial houses have started exploiting the plants indiscriminately. The raw materials of herbal drugs, which are mostly, collected wild and the supply line is adversely affected, leading to adulteration and substitution for genuine drugs. As the medicinal plants are collected by untrained collectors basing on the Sanskrit names or local names, there is a chance of misidentification out of ignorance due to similar vernacular name. The present study was conducted with an aim of developing standard marker for proper identification of raw materials. In this investigation, the parameters adopted for identification of seeds of A. graveolens include physico-chemical values, fluorescence analysis and powder microscopy to develop their chemical parameters and diagnostic microscopic characters.

Keywords: ‘Ajmoda’, pharmacognosy, Apium,


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