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Abstract

EVALUATION OF ANTI-ULCER ACTIVITY OF ACTIVE FRACTION OF HELICTERES ISORA LINN. FRUIT EXTRACT

Chakraborti S.*, Pattnaik A. K., Kumari S., Mohanty S.

ABSTRACT

Peptic ulceration is considered to be one of the modern age epidemics, has been affecting approximately 10% of world population. Peptic ulcer occurs due to an imbalance between acid and pepsin along with the weakness of the mucosal barrier. Due to these, it is commonly associated with damage of the stomach’s mucosal layer, which is simply generated via excess generation of exogenous and endogenous active oxygen and free radicals. Some of the main causes of gastric ulcers include chronic use of alcoholic beverages and antiinflammatory drugs, as well as stress and Helicobacter pyroli infection In this study phytochemical screening of the fruits of Helicteres isora Linn. were performed to find out the existence of various phytoconstituents. Then in vitro studies were carried out to check various antioxidant property using hydrogen peroxide scavenging assay, DPPH radical scavenging activity, estimation of total phenolic content and total flavonoid content. Animal models were developed by aspirin+pyloric ligation method and ethanol ligation method on Wistar rats. The chosen drug showed a potent antiulcer activity, the effect may be attributed to the presence of flavonoids in the extract. Flavonoids are responsible for the free radical scavenging activity and are believed to be one of the important components in antiulcer activity. Potent free radical scavenging activity was found for active sub-fractions of ethyl acetate extract of Helicteres isora Linn. This study showed a potent antiulcer activity of the most active fraction of Helicteres isora Linn. that suggests, ethnopharmacological approach in selecting the plant for study may be useful.

Keywords: Helicteres isora Linn. fruit extract, Pylorus ligation, HCl/ethanol induced ulcer, Flavonoids, Anti-ulcer activity, Ranitidine, Omeprazole.


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