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Abstract

ESTIMATION OF IMIDAPRIL HYDROCHLORIDE BY UV - VISIBLE SPECTROSCOPIC METHOD IN DIFFERENT SOLVENTS

P. Prapulla*, B. Babu, T. Maheshwari, K. Paramesh, G. Swathi and K. Madhavi and K. Hemamalini

ABSTRACT

The objective of the project work was to developed and validated simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quantitative estimation of Imidapril HCl in different solvents like 0.1N HCl, Distilled water and 0.1N NaOH in bulk based on measurement of absorption at maximum wavelength and validated as per ICH guidelines. Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. Imidapril HCl showed absorption maximum (λmax) in different manner in different solvents like 0.1N Hydrochloric acid, Distilled Water and 0.1N Sodium Hydroxide Solution at 217 nm, 293 nm, and 236 nm respectively. The drug exhibited maximum wavelength (nm) in distilled water, 293 nm when compared with other solvents due to the effect of solvent and chromophoric group. Thus the conclusion was made that the proposed UV Spectrophotometric method were found to be simple, rapid, accurate, precise, linear and more economical method has been developed for the quantitative estimation of imidapril HCl in bulk. Hence, this method can be successfully and suitably acquired for routine quality control analysis of imidapril HC in bulk form.

Keywords: Imidapril HCl, Method development, UV Spectrophotometer, Validation.


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