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Abstract

INFLUENCE OF AQUEOUS EXTRACT OF ANNONA SENEGALENSIS LEAVES ON SOME PARAMETERS OF INFLAMMATION ON RAT SPECIALLY THOSE OF ‘WISTAR’ ORIGIN

Manouan Miézou Annick Marina*, Yeo Dodéhé, Thès Pehie Marie Epse Soumahoro, Djaman Allico Joseph

ABSTRACT

The present study was carried out on medicinal plants had for target to establish the influence of the aqueous extract of Annona senegalensis leaves in various doses on the edema prevention and the quantity of protein C Réactive (CRP) during an inflammatory process. For this experiment, 20 rats of middle weight of 160 g were divided into 5 random group. One control group received no treatment, another reference batch received 1 ml/100g body weight of diclofenac and the other three lots received 250, 500 and 750 ml / mg / kg body weight respectively of Aqueous total extract (ETA) of Annona senegalensis leaves. The edema is caused 30 minutes later by the injection of carrageenan 1% in sub-plantar region right of paw of each rat. The diameter of the rats paw is measured before and after the injection of carrageenan up to 4 hours of experimentation. However, the ETA in the dose of 750 ml/mg/kg PC had the best prevention of the edema with 55.02 percent of inhibition. The dosage of CRP in the serum of the rats of the various group revealed a lower quantity of CRP in the serum of rats having received the ETA in the dose of 750 ml / mg / kg PC. There was no significant difference between the effect of the diclofenac and the ETA in the dose of 750 ml / mg / kg PC on the inhibition of the edema and the decrease of the quantity of CRP in the serum. The anti-inflammatory activity of Annona senegalensis leaves demonstrated in this study is greater at the dose of 750 ml / mg / kg PC. This activity put the scientific foundation for the use of the leaves of this plant for the traditional treatment of various inflammatory diseases. Nevertheless, studies must study the action mode of this plant and the purification of the active ingredients responsible for the effects of this plant.

Keywords: Annona senegalensis, inflammation, carrageenan, edema, CRP.


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