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Abstract

FORMULATION AND EVALUATION OF WOUND HEALING ACTIVITY OF MACROPTILIUM ATROPURPUREUM IN ALBINO WISTAR RATS

*Mohd Shahed Ali, Mohd Rafiq and Dr. Shaik Mohd Khasim

ABSTRACT

Considering various adverse affects associated with synthetic medicines, researchers are shifting their thinking towards herbal based medicines which are safe to use. Throughout the world tribal’s as well as the folklore traditions used a huge number of plant extracts for various elements including curing cuts, wounds, bruises and burns. Wounds are physical injuries that result in an opening or breaking of the skin. Whereas healing is a natural phenomenon by which body itself overcome the damaged to the tissue but the rate of healing is very slow and chance of microbial infection is high. Therefore proper healing of wounds is essential for the restoration of disrupted anatomical stability and disturbed functional status of the skin. The present attempt is to highlight wound healing potential of petroleum ether and aqueous extract of Macroptilium atropurpureum (200mg/kg/day) in wistar albino rat using excision and incision wound model in the form of ointment base. All experiments were conducted according to standard procedures. The parameters studied were breaking strength in case of incision wounds and epithelialisation and wound contraction in case of excision wound. The results obtained indicated that Macroptilium atropurpureum posses extreme significant (P<0.0001) of wound healing process when compared to control group and somewhat similar to standard (i.e, Silver sulfadiazine).

Keywords: Macroptilium atropurpureum, Wound healing, Excision wound, Incision wound, Silver Sulfadiazine Ointment.


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