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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL POTENTIAL OF QUINAZOLONES, Beta- LACTUM AND PRIMIDINE MOIETIES

Jyotindra J. Bhatt*, Viram Vadher, Girin Baxi and Mrugesh H. Trivedi

ABSTRACT

Since 1900, medicinal and pharmaceutical fields are taking benefits of Beta Lactam derivatives for their wide spectrum of biological activities. They are 4-membered cyclic amides though the first member was synthesized by Staudinger in 1907, the Beta lactams has got better attraction since the discovery of penicillin which contains preparation of Anthranilic acid to Iodo Anthranilic acid. The present study was aimed for the synthesis of Quinazolones, 6- Lactum and Primidine moieties and its different Schiff Bases using different aldehyde like (1) Veratraldehyde, (2) 3,4- Dicloro Benzaldehyde, (3) 3 Nitro Benzaldehyde, (4) Salisaldehyde, (5) 4-Flouro Benzaldehyde. The synthetic compounds were confirmed for their preparation using FTIR. Antimicrobial activity was also checked against Staphylococcus Sp., Aureus, E. Coli and Pseudomonas. The derivatives of Beta Lectam synthesised in the lab found significant activity against the pathogens and need further research to develop important antibiotic in future after completing advance drug testing studies.

Keywords: Antimicrobial activity, Quinazolones, 6- Lactum, Primidine, Schiff Base.


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