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Abstract

ENHANCED GLYCEMIC CONTROL, PANCREAS PROTECTIVE, MODULATED CARBOHYDRATE METABOLIC ENZYME ACTIVITIES BY ZINGERONE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

M. Arul Jothi, C. S. Parameswari* and S. Vincent

ABSTRACT

Objective: To investigate the glycemic control, pancreas protective, modulated carbohydrate metabolic enzyme activities by Zingerone in STZ induced diabetic rats by administering oral doses (10mg/kg body weight). Methods: Blood glucose levels were measured using Liqui CHEK glucose assay kit (Agappe Diagnostic Ltd., India) at weekly intervals (i.e. 0, 7, 14, 21 and 28 days) till the end of study. Serum insulin levels were measured by Enzyme Linked Immuno Sorbent Assay (ELISA) using the rat insulin ELISA kit (BioGenes GmbH, Germany). Carbohydrate metabolic enzymes hexokinase, glucose-6- phosphatase, glucose-6-phosphate dehydrogenase and fructose-1,6- bisphosphatase were evaluated. Histopathological changes in diabetic rat organ (pancreas) were also observed after the 30 days treatment. Results: Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (STZ) (40 mg/kg body weight). Five days after STZ administration, diabetic rats received zingerone (10 mg/kg body weight) orally for 30 days. Metformin (Met) was used as reference drug. Zingerone treatment significantly reduced blood glucose level with an increase in the level of insulin. The zingerone-treated diabetic rats sustained their initial weights during the treatment period. We observed increase in the activity of carbohydrate metabolizing enzymes including hexokinase, glucose-6-phosphate-dehydrogenase and glycogen content in liver of Zingerone treated rats with reduction in the levels of glucose-6-phosphatase and fructose-1,6-bisphosphatase. Conclusion: These findings substantiated the beneficial effects of Zio in the treatment of diabetes through exhibiting antihyperglycemic effects as well as restoring the function of pancreas. Thus, zingerone may have the potential in managing the effects of diabetic complications in human subjects.

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