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Abstract

SPECTROPHOTOMETRIC DETERMINATION OF AZILSARTAN MEDOXOMIL IN A PHARMACEUTICAL PREPARATION BY POTASSIUM PERMANGANATE AND SULPHANILIC ACID

Ritika Makhijani*, Vighnesh Nalawade, Divyadarshni Balasubramaniam and Vasant D. Barhate

ABSTRACT

For the detection of Azilsartan Medoxomil two simple and sensitive spectrophotometric methods are developed. The first method A is based on the addition of excess KMnO4 of known concentration in the presence of 2M H2SO4, reactants are allowed to react and the unreacted KMnO4 is estimated with a fixed amount of Methyl Orange by measuring the absorbance at 510nm. Beer’s law was obeyed in the concentration range of 0.5- 5 μg /ml Molar absorptivity was found to be 4.25 X 104 L mol-1cm. The second Method B is based on the formation of orange color as a result of reaction between drug and diazotised Sulfanilic acid absorbance was measured at 510 nm. All parameters affecting the development of the color were investigated and the conditions were optimized. Under the optimum condition, Beer’s law was obeyed in the concentration range 1- 8 μg/ml. Molar absorptivity was found to be 1.348 X 104 L mol-1 cm-1. The proposed methods are well suited for determination of Azilsartan Medoxomil in pharmaceutical formulations.

Keywords: Azilsartan Medoxomil, Potassium Permanganate, Daizotised Sulphanilic Acid, Spectrophotometry, methylorange, Oxidation.


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