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Abstract

OXIDATIVE SPECTROPHOTOMETRIC DETERMINATION OF DRUGS IN PHARMACEUTICAL FORMULATION USING NBROMOSUCCINAMIDE AS AN OXIDANT AND SAFRANIN-O DYE

Munnuru Pandurangam and A. Panasareddy*

ABSTRACT

A simple, sensitive and selective method has been developed for the spectrophotometric determination of drugs, viz., Moxifloxacin, Ramipril, Samaritan, Trimetazidine and Lacosamide. The proposed method involve the addition of excess NBS of known concentration in the presence of acidic medium and the unreacted NBS is determined by the measurement of the decrease in the absorbance of the dye safranin- o blue (λmax 532 nm). The colored species in acidic medium, reactants are allowed to react and the unreacted NBS is estimated by the measurement in the decrease in the absorbance of the safranin-o dye (λmax 532 nm). This method has been validated in terms of guidelines of ICH and applied to the quantification of selected drugs in bulk and dosage forms.

Keywords: Spectrophotometry, Drugs, NBS, Safranin-o, Quantification, Validation.


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