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Abstract

FORMULATION AND EVALUATION OF BILAYER TABLET OF AMBROXOL HCL AND DESLORATADINE FOR THE TREATMENT OF SEASONAL ALLERGIC RHINITIS ASSOCIATED WITH COUGH.

Sonia Sharma* and Shweta Agarwal

ABSTRACT

The present study was intended at raising a bilayer drug delivery system containing Ambroxol HCL and Desloratadine for the treatment of moderate seasonal allergic rhinitis (SAR), to reduce the dose frequency and to improve the prolongation of action. The tablet is characterize by conventional release of Desloratadine and sustained release of Ambroxol HCl. The formulation containing sustained release layer of Ambroxol HCl, was designed using HPMC-5 CPS as sustained release polymer, MCC as drug binder, Aerosil to improve flow properties of powder, and Magnesium stearate as antiadherent agent. Crosspovidone was used as superdisintegrant for the preparation of conventional release layer. The prepared sustained release layer was evaluated for their pre-compression parameters, physical characteristics like hardness, friability, and weight uniformity, disintegration, and uniformity of drug content and in- vitro drug release. The release of Desloratadine from the conventional release layer was found to be within 30 min. The release of Ambroxol HCl for sustained release layer was found to be in 6 hours.

Keywords: Ambroxol HCL, Desloratadine, bilayer tablet, crosspovidone, superdisintegrant.


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