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Abstract

IMPROVEMENT OF GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF BRASSICA RAPA SUBSP. RAPA ROOTS AND ZINGIBER OFFICINALE RHIZOMES

Shahanoor Rohani, Md. Sohel Rana, Md. Najmul Hossain and Mohammed Rahmatullah*

ABSTRACT

Background. Brassica rapa subsp. rapa (Brassicaceae family) and Zingiber officinale (Zingiberaceae family) are two plants cultivated in Bangladesh, respectively, for consumption as vegetable and as spice. A number of Brassicaceae and Zingiberaceae family plants have previously been reported to have antihyperglycemic properties. It was therefore of interest to determine the antihyperglycemic potential of a polyherbal formulation containing the roots of the first and rhizomes of the second plant. Methods. Oral glucose tolerance test (OGTT) was done to evaluate antihyperglycemic potential. Results. In oral glucose tolerance tests, methanol extract of roots of Brassica rapa subsp. rapa (MEBRR), administered at a dose of 400 mg per kg body weight reduced blood glucose by 30.8%. Methanol extract of rhizomes of Zingiber officinale (MEZO), administered at the same dose reduced blood glucose by 33.6%. Administration of a combination of MEBRR and MEZO (1:1, w/w), tentatively termed MEBRZO, significantly and dose-dependently reduced blood glucose levels in glucose-loaded mice by 32.5, 36.3, 40.4, and 44.5%, respectively, at doses of 50, 100, 200 and 400 mg each per kg body weight in mice. By comparison, a standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels by 46.9% at a dose of 10 mg per kg. Conclusion. MEBRZO can be used as a source for blood glucose lowering in diabetic patients in the absence of antihyperglycemic drugs.

Keywords: Antihyperglycemic, Brassica rapa subsp. rapa, OGTT, Zingiber officinale.


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