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Abstract

EVOLUTION OF TUMOR SUPPRESSOR P16INK4A EXPRESSION IN CERVICAL CARCINOMA AMONG IRAQI WOMEN PATIENTS

Dr. Athraa Zaidan Hassan* and Hassan Yasir Jaber

ABSTRACT

Background and objective: p16INK4a (p16) is a tumor suppressor protein belongs to the family of INK4 a cyclin-dependent – kinase inhibitor. As overexpression of the protein p16 is correlated with the presence of high-risk HPV in malignant cervical lesions. This protein has been proposed as a surrogate marker of high-risk HPV infection in cervical cancer screening. Since high-risk viral DNA integration is necessary for neoplastic progression, we aimed to examine the expression of p16 in cervical cancer and determined any associated between presence of high risk of human papilloma virus and expression of p16 in cervial carcinoma among Iraqi women patients. Method: This study was carried out on 30 patients with hisopathologically confirmed primary cervical cancer in addition 20 cervical tissues from control individuals with no cancer as control groups. From each patients and control cervical tissues were proposed for chromogen in situ hybridization (CISH) techniques to investigation the presence of HPV (HPV 16 /18) DNA CISH in cervical tissues and for immunohistochemistry was used to detected expression of p16. Results: P16 expression was found in 28/ 30 (98%) tumor sample while negative cases in 2/30 (6%) tumor sample and no expression of p16 in cervical control groups. In this study demonstrated that all cervical carcinoma cases which positive for HPV (16/18) which represented 26/30 from the cases also positive for p16 expression (100%). Conclusion: Significant association obtained between p16 expression and high risk of HPV 16/18 CISH results in cervical carcinoma which indicate that inactivation of retinoblastoma protein (Rb) by E7 of HPV 16/18 among Iraqi women patients.

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