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Abstract

APPLICATION OF UV SPECTROPHOTOMETERIN METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANIOUS ESTIMATION OF GABAPENTIN AND MECOBALAMINE IN PHARMACEUTICAL DOSAGE FORM

Sonali T. Gade*, Narwate B. M., Swati B. Fulsaundar and Sonawane M.D.

ABSTRACT

Two precise, simple, accurate, reproducible, rapid and economical UV
spectrophotometric methods have been developed for simultaneous
estimation of gabapentine and mecobalamine in tablet dosage form by
using 0.1N HCL as solvent. Method I is based on formation and
solving of simultaneous equation method, known as vierodt’s method.
Gabapentine and mecobalamine show absorbance maxima at 283 nm
and 274 nm respectively, so absorbance was measured at the same
wavelength for the estimation of gabapentine and mecobalamine in
tablet combination. Method II is based on principle of Q-analysis,
known as absorbance ratio method. Absorbance was measured at 285
nm (isobestic point) and 274 nm (λmax of Methylcobalamin.).
gabapentine and mecobalamine obeys beer’s law in the concentration range of 5 to 30 μg/ml.
Percentage estimation of gabapentine and mecobalamine in tablet dosage form by method I
is 99 and 99.85 and by method II is 99 and 99.89 respectively with standard deviation ≤2.
Methods are validated according to ICH guidelines and can be applied for routine analysis of
drugs in tablet dosage form.

Keywords: Gabapentine and mecobalamine.


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