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Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF NICORANDIL

Nagoba Shivappa N.*, Bondar Ganesh H., Gaddime Sonali B., Vijayendra Swamy S. M.

ABSTRACT

Transdermal patch has made an important contribution to medical practice. It is a medicated patch that delivers a specific amount of medication through the skin into the blood stream. An advantage of a transdermal patch route over other types of medication delivery is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The present investigation was aimed to formulate transdermal patches of Nicorandil drug with different ratios of Ethyl cellulose7Cps and Eudragit Rs 100 polymeric systems by the solvent evaporation technique by using Diethyl phthalate to the polymer weight, incorporated as plasticizer. To enhance the permeation of drug through the skin by using different types of penetration enhancer like as DMSO, DMF, and Oleic acid. The prepared matrix patches were evaluated for their physicochemical characterization followed by weight variation, drug content estimation, folding endurance, moisture uptake, moisture loss, FTIR, skin irritation and in vitro diffusion studies. The in vitro diffusion release study from different transdermal patches across the dialysis membrane. Polymer concentration of (Ethyl cellulose7 Cps: Eudragit RS 100) w/w in each type of as polymer Patch was found to be best. As the polymer concentration increase to be used 1:1 w/w, 2:1 w/w, 3:1w/w ratio. Ethyl cellulose in concentration of 1% showed best release as compared to other concentrations.

Keywords: Transdermal patches, Nicorandil, Ethyl cellulose 7-cps, Eudragit RS 100, Penetration Enhancer.


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