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Abstract

STUDIES ON ACUTE TOXICITY PROFILE AND UTERINE HISTOPATHOLOGICAL CHANGES AFTER UTERINE IMPLANTATION OF SMA-COATED AND NON-COATED COPPER T (CU-T) IN RATS

Falgun Wanganuji Bansode, Anil Kumar Meena and Rama Kant Singh*

ABSTRACT

The non-hormonal contraceptive, named RISUG (an acronym for Reversible Inhibition of Sperm under Guidance) has expected to provide a valuable addition to the current options of male contraception. Present study was conducted to assess the toxic effects after uterine implantation of SMA-coated Cu-T and non-coated Cu-T in female Charles Foster rats. Healthy adult female rats of were randomly divided into two groups (Grs.) consisting 10 animals each. Gr. I. rats were implanted with non-coated Cu-T in both uterine horns served as control. Rats in G.II were implanted with SMA-coated Cu-T in the uterus bilaterally and observed for a period of 14 days. The initial (on day 0) and final (on day 15) body weights, food and water consumption in control and treated animals were recorded. Blood samples were collected in EDTA-coated vials for haematological and biochemical analysis. On day 15, autopsy of animals was done and body organs (viz. liver, lungs, kidney, uterus, fallopian tubes and ovaries) were dissected out surgically, then weighed and fixed in formalin for histopathological study. Results showed that the body weights, absolute/relative organ weights, food and water consumption, hematological parameters, viz. Hgb(g%), RBC(x106/mm3), Hct(%), MCV(micron3), MCHC(g%), TLC(x103/mm3), DLC(%) of Polymorphs, Lymphocytes, Macrophages, Eosinophils and Platelets (x103/mm3), and biochemical analysis of marker enzymes, did not show any significant changes in SMAcoated Cu-T as compared non-coated Cu-T group of rats. There were no any toxic effects or mortality observed during the entire treatment period. The microscopic examination of histological slides of the vital organs and uterus, ovary and fallopian tubes did not reveal any significant pathological changes as compared to controls. Results of the study show that uterine implantation of SMA-coated Cu-T and non-coated Cu-T did not reveal any adverse effects during 14 days toxicity study in rat. Thus, indicate that it is safe to use for further studies.

Keywords: SMA-coated Copper T, Non-coated Copper T, Intra-uterine implantation, Toxicity profile, Rats.


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