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Abstract

FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF FUROSEMIDE

Warkari Rajan D., Nagoba Shivappa N.*, Shimge Krishna R. and Sarukh Vikram S.

ABSTRACT

Orally disintegrating tablets (ODTs) are a rapidly growing category of dosage form in the pharmaceutical industry which has received everincreasing demand during the last decade. They especially find application in target category like geriatrics and pediatrics. There are three main manufacturing methods used for the production of ODTs, namely, freeze drying, molding and compression method. Some methods of manufacturing ODTs are complex, require multiple processes and don’t provide all ODTs ideal properties. For example, freeze drying and molding provide very light and porous products which disintegrate very rapidly, but they are expensive and produce fragile products. On the other hand, compression method is the easiest and cost effective method for the production of ODTs. Orally disintegrating tablets containing 20 mg of Furosemide were manufactured using direct compression method. Experiments were evaluated for effects of formulation parameters like type & concentration of diluents, concentration of disintegrating agent and their interactions on Furosemide ODTs properties, and Microcrystalline cellulose, Mannitol were used as diluents of different properties, in addition to croscarmellose sodium (CCS) and Crospovidone which was used as a superdisintegrants. The obtained results revealed that disintegration time of the optimized ODTs formula (35 sec. to 50 sec). ODTs composed of croscarmellose sodium superdisintegrants was optimized formula, as it showed the lowest disintegration time with the highest drug release up to 92.70%. Furthermore, hardness of the manufactured tablets was not significantly affected by the use of Crospovidone and CCS. Finally, it was concluded that Furosemide oral disintegrating tablets were developed using croscarmellose sodium. These tablets provided low disintegration time and high hardness that are acceptable for ODTs.

Keywords: Orally disintegrating tablet, Croscarmellose sodium, Crospovidone, Furosemide.


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