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Abstract

FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL DISINTEGRATING TABLETS

V. Anilkmuar*, B. Padmasri, R. Kalyani and D. Prasanth

ABSTRACT

Over the past three decades, orally disintegrating tablets(ODTs) have considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. United States Food and Drug administration (FDA) defined ODT as “ A Solid dosage form containing medicinal substance or active ingredient which disintegrates rapidly usually with in a matter of seconds when placed upon the tongue”. Almotriptan is an extremely potent member of triptan class drugs which is widely used in the treatment of migraine. It shows high bioavailability, rapid action with fewer side effects when compared to other drugs of the same class. The present study is aimed to develop an oral disintegrating solid dosage form of Almotriptan which disintegrates rapidly without the need of water or chewing and release its drug instantaneously showing rapid action for sudden attacks of migraine with good patient compliance for all age groups. Crosspovidone & SSG were selected as super disintegrants. FTIR studies were carried out to confirm the drug excipients compatability. Pre compression evaluation tests and post compression evaluation tests were also carried out as the tablets are ODTs wetting time and water absorption studies were also carried out. The evaluation results confirmed that the crosspovidone is more suitable to SSG and Almotriptan can be best formulated as ODT using crosspovidone.

Keywords: Over the past three decades, ODT using crosspovidone.


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