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Abstract

STUDY DIURETIC ACTION OF LEAVES OF MANGIFERA INDICA

Abhishek R. Bura*

ABSTRACT

A dried powder of Mangifera Indica is substituted for extraction using
ethyl acetate,60 % ethanol, and water in upper order to polarity
prepared. Mangifera Indica L. indicates the presence of alkaloids,
tannins, saponins, steroids, flavonoids, terpenes by phytochemical
analysis of ethanolic extract. Then diuretic activity tested by Aqueous
and 60 % ethanolic extract of Mangifera Indica. Diuretic activity tested
by Lipchitz method. In toxicity studies 200mg/kg & 400 mg/ kg dose
was selected for given activity. After 24 hours urine output was
calculated. In the given study Furosemide (20mg/kg) served as a
positive control by giving IP route and by giving IV route and by oral
route extracts were given. Na+, K+, Cl concentration in urine was
determined by flame photometer instrument.60% ethanoic extract and aqueous extract of
Mangifera Indica L. leaves at 400 mg/kg have increased the urine output significantly. These
extracts of 60 % EEMI & AEMI at 400 mg/kg b.w. has shown better diuretic activity,
whereas moderate diuretic activity was shown at 200 mg/kg dose. From current study, it is
concluded that aqueous extract and 60% ethanolic extract of Mangifera Indica L. has diuretic
and natriuretic activity.

Keywords: Mangifera Indica L., Na+/ K+ ratio, Diuretic, Photochemical.


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