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Abstract

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF HETEROCYCLES CONTAINING BISTHIAZOLIDINE RING USING HALOVINYL ALDEHYDES

Javed Hanif Mansoory and Shankarsing Sardarsing Rajput*

ABSTRACT

A series of novel bis-thiazolidine derivatives with pyrrole ring was designed and synthesized. N-phenyl succinimide on haloformylation with Vilsmeier-Haack reagent (DMF/POCl3) furnished halovinyl aldehyde which on condensation with l-cysteine afforded the target compounds in catalytic amount of piperdine. The synthesized compounds were characterised by spectral analysis. Biological screening shows some of the synthesized compounds exhibit good anti-microbial activity.

Keywords: Bis-thiazolidine, halovinyl aldehydes, di-halo formy lation, DMF/POCl3.


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