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Abstract

PHARMACOGNOSTICAL AND PHYTO-CHEMICAL STANDARDIZATION OF VARUNADI CHOORNA- A POLYHERBAL FORMULATION

Dr. Sajeewane M. S.*, L. P. Dei, Harisha C. R. and V. J. Shukla

ABSTRACT

Introduction: Uterine fibroids do not have definite medical treatment in the modern gynaecological practices other than surgery. When we consider about the present scenario of this disease which is needed to find out appropriate and effective solution of this problem. So many formulations are advised in Ayurveda classics under the Granthi Arbuda and Apachi Chikitsa along with some specific lifestyle restrictions. Ayurveda texts have described Mamsaja granthi which perfectly correlates with benign neoplasm on modern lines. Granthi when present in yoni (female reproductive system) Garbhashaya (uterus) will lead to disturbed menstrual cycle-menorrhagia, metrorrhagia, dysmenorrhea, etc., along with infertility. Most of the Ayurvedic drugs are very effective but lack standardisation. Varunadi decoction is mentioned in Sri Lankan Ayurveda Pharmacopeia which is commonly used by Sri Lankan Traditional Medical Practitioners for Garbhasayagata Granthi/Arbuda. Varunadi choorna was selected as the trial drug for uterine fibroid. Aim: To develop the pharmacognostical and phytochemical profile of Varunadi choorna. Material and Methods: Varunadi choorna was prepared as per classical methods and analytical findings were systematically recorded. The samples were subjected to organoleptic analysis, physicochemical analysis and HPTLC examination by optimizing the solvent systems. Results and Conclusions: Pharmacognostical profile of Varunadi choorna was established. The presence of Stone cells, cork cell in surface view, cluster crystal, lignified stone cells. Pitted stone cell with greenish content, Rhomboidal crystal were the characteristic features observed in the microscopy of the finished product. Physico-chemical analysis showed Loss on drying 0.02% w/w, ash value 0.91% w/w, and pH- 6.5. Water soluble extract 12.50 % (w/w), HPTLC fingerprinting profile of Varunadi choorna revealed 10 spots at 254 nm and 5 spots at 366 nm.

Keywords: Organoleptic, Pharmacognosy, HPTLC, Uterine fibroid, Varunadi choorna, Physio-chemical.


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