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Abstract

ANTIDIABETIC ACTIVITY OF RHUS AROMATICA MOTHER TINCTURE ON DIABETIC MALE WISTAR ALBINO RATS

*Deepa P. and Jayachandran T. P.

ABSTRACT

Objectives: The aim of this study was to assess the antidiabetic effect of Rhus arom Q mother tincture on diabetic wistar albino rats. Methods: Diabetic induction in wistar albino rats was performed as per standard method using alloxan at the dose 150mg/kg body weight. After overnight fasting diabetes was induced in rats by single intraperitoneal injection of Alloxan monohydrate dissolved in normal saline at a dose of 150mg/kg body weight. Dose of the mother tincture(1ml/kg) were administered to normal and experimental diabetic rats for 14 days. The blood samples were withdrawn from the retro orbital sinus on 1,7 and 14th days of mother tincture administration. Fasting blood glucose level and change in body weight also examined on these days. OGTT and histopathological studies of Pancreas, liver and kidney were also performed. Serum lipid profiles were also performed. Results and Discussion: In in vivo study, Rhus arom Q mother tincture showed a decrease in fasting blood glucose levels. All these effects compared with Syzigium jambolanum MT(Homeopathic standard) and Glibenclamide 0.6mg/kg as a reference drug. The administration resulted in significant decrease in level of blood glucose and lipid profile. The total cholesterol and serum triglycerides levels were also reduced and the HDL cholesterol level were increased upon treatment with the Rhus arom Q mother tincture thus providing the potent antidiabetic property of the mother tincture. Recovery of body weight of mother tincture treated diabetic rats gave further evidence for dose related antidiabetic activity of Rhus arom Q. The mechanism involves potentiation of the insulin effect to plasma by increasing pancreatic secretion of insulin from the existing beta cells and it also inhibited cholesterol and triglyceride synthesis. The mother tincture of Rhus arom Q significantly increases glucose tolerance of normal animals, which further confirms the safety and antidiabetogenic action of the Rhus arom Q mother tincture. Conclusion: The in vivo study confirmed the antidiabetic activity of Rhus aromatica mother tincture.

Keywords: Diabetes, Mothertincture, Rhus aromatica, Lipid profile.


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