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Abstract

PRESCRIBING TRENDS IN PARKINSON’S DISEASE AND RISK FACTORS INVOLVED WITH LEVODOPA INDUCED MOTOR COMPLICATION IN A TERITIARY CARE HOSPITAL

Prof. Dr. Mathew George*, Prof. Dr. Lincy Joseph, Mincy Mathew, Jiya Ann Mathew and Teena Thomas

ABSTRACT

Parkinson’s disease is the second most common neurodegenerative disorder and also a common movement disorder. The progression of Parkinson’s disease and the degree of impairment vary from person to person. The aim of this study was to ascertain the prescribing pattern of anti- Parkinson drugs and also the risk factors involved with motor complications developed by the use of levodopa. 60 patients with clinically definite idiopathic parkinson’s disease were studied. Among the patients, number of anti-parkinson’s drugs prescribed increased with disease duration and severity. From the study result, most commonly prescribed anti Parkinson drug was levodopa carbidopa combination. Along with this drug anti-cholinergic and dopamine agonist were mostly prescribed. commonly prescribed concurrent drugs other than anti Parkinson drugs are for cardiac, mental and neurological disorder. Among 60 patients, 31.7% were experiencing dyskinesia 65% were have OFF periods. Total dose of levodopa, levodopa equivalent daily dose, disease duration and treatment duration with levodopa has significant association with dyskinetic movement. Our study provides a basic knowledge about the drug prescribing pattern in the treatment of parkinson disease and also highlight the known risk factors of levodopa induced motor complication.

Keywords: Parkinson Disease, Levodopa, Dyskinesia, Prescribing Pattern.


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