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Abstract

EFFECT OF DEGLYCYRRHINATED LICORICE ON LEARNING AND MEMORY IN RATS ASSESSED BY HEBB WILLIAM MAZE AND ELEVATED PLUS MAZE

Mangala Srinivas*, Ravichandra Volabailu and Sangeeta Nath Sharma

ABSTRACT

Context: The glycyrrhiza glabra(licorice) has shown a neuroprotective role. Deglycyrrhinated licorice (DGL) preparations is made from licorice from which the glycyrrhizin has been removed. Aims: To evaluate the effects of Deglycyrrhinated licorice (DGL) in diazepam induced impairment of learning & memory in rats. Settings and Design: Animals were grouped into 6 groups(n=6), Group 1(control) received the vehicle, group 2 & group 3 animals received DGL a licorice root extract of 10mg/kg & 13.5mg/kg respectively. Group 4 diazepam of (1mg/kg i.p) was given. Group 5 & group 6 received DGL 10mg/kg & 13.5mg/kg respectively for 10 days and on 10th day diazepam 1mg/kg was administered. Methods and Material: The transfer latency (TL), time taken to reach reward chamber (TRC) using EPM and HWM respectively, was evaluated on 10th & 11th day. Statistical analysis used: Analysed using Non-parametric measure – Median ± Interquartile range (IQR), where P value <0.05 was considered significant. Results: The TL & TRC was significantly reduced in DGL (13.5mg/kg) & even diazepam induced amnesia was reversed showing memory enhancing activity. Conclusions: In our study DGL has shown a memory enhancing property in laboratory models employed.

Keywords: Deglycyrrhinated, licorice, learning, memory, Diazepam, amnesia.


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