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Abstract

FORMULATION AND DEVELOPMENT OF FAST DISINTEGRATING ORAL FILM

Vaibhav Khodke*, Suraj Yadav and Amol Sawale

ABSTRACT

The fast-dissolving drug delivery system is advancement for innovative formulation and development. The present study was aimed to formulate and evaluate fast dissolving oral films of Azilsartan Medoxomil using HPMC propylene glycol pvp k30 and fenugreek. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by Solvent casting and Hot melt extrusions method, characterized by palatability study and electron scanning microscopy. The films were evaluated for Palatability Studies, disintegration time, Folding endurance, swelling property, surface PH, Tensile Strength, Mouth dissolving time, Thickness, content uniformity and In-vitro dissolution studies. The F3 formulation has given 98.5% drug release within 3.41 minutes and has a tensile strength of 5.08(kg/mm2).

Keywords: Azilsartan Medoxomil, HPMC, super disintegrants, fast dissolving oral film, solvent casting method.


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