ATOMIC ABSORPTION SPECTROMETRIC DETERMINATION OF METOCLOPRAMIDE HYDROCHLORIDE USING AMMONIUM REINECKATE
Mohammad Wafaa I. Nassar, Khalid Abdel-Salam M. Attia, Ahmed Abdelhalim A.
Mohamad, Ragab Ahmad M. Said and Rady Fathy A. Gaber*
ABSTRACT
An accurate, rapid and simple atomic absorption spectrometric method
was developed for the determination of metoclopramide hydrochloride
(MCP-HCl). The proposed method has been depended on the reaction
of ammonium reineckate with MCP-HCl to form a stable precipitate of
ion-pair complex, which was dissolved in acetone. The pink colored
complex was determined by atomic absorption spectrometer at
wavelength 357.9 nm. The studied drug could be evaluated in the
range of 20 ─ 120 μg/mL. The optimization of various experimental
conditions was described. The results obtained showed good accuracy
of 99.36 with repeatability of 0.854 and intermediate precision of
1.351. Application of the proposed method to representative
pharmaceutical formulation was successfully presented.
Keywords: Ammonium reineckate, atomic absorption spectrometric method, ion-pair complex, metoclopramide.
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