WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COMPATIBILITY ASSESSMENT OF QUERCUS INFECTORIA GALLS (FAGACEAE) ETHANOLIC EXTRACT WITH CARBOPOL 940 AND XANTHAN GUM POLYMERS AS PRE-FORMULATION STUDY

*Fatehalrahman F. Magbool, Elamin Ibrahim Elnima, Shayoub M. E. and Elnazeer I. Hamedelniel

ABSTRACT

The galls of the Quercus infectoria (Family Fagaceae), traditionally believed to have great medicinal value. Pharmacologically the galls are claimed to have various biological activities. The our previous preliminary phytochemical screening study done was performed to establish the profile of galls extract for its chemical composition, the Q. infectoria galls extract showed the presence of tannins, flavonoids, saponins, anthraquinones, triterpenes and cumarines. These secondary metabolites exert antimicrobial activity through different mechanisms. Also in our previous study the ethanolic extract of the Q. infectoria galls was tested for their bioactivity against C. albicans. Extract of Q infectoria galls showed potential activity against the tested fungal isolate. Medicinal plant extracts are API’s of great interest for the pharmaceutical industry and have been used as final and intermediate products, resulting in different pharmaceutical forms. Thus, the aim of this study is to evaluate the physical and chemical compatibilities of the ethanolic extract of Q. infectoria galls, with pharmaceutical excipients (carbopol 940 and xanthan gum) used in the formulation of pharmaceutical oral gel dosage form. In physical compatibility study each excipient was thoroughly blended with Q. infectoria galls extract to increase drug-excipients molecular contacts and also to accelerate the reaction if possible. Chemical compatibility of the Q. infectoria galls extract with carbopol 940 and xanthan gum was determined by FT-IR spectral analysis. Physical compatibility study showed that after 30 days storage of drug extract with excipients in various ratio at room temperature, there is no physical changes observed in the mixture of extract and polymer combinations. FT-IR study showed that there was no major change in the position of peak obtained in the drug alone and in a mixture of extract with excipients, which shows that were no chemical instabilities in drug – excipient combinations, suggesting no evidence of interactions between the functional groups of these components. Based on our results, all mentioned excipients were found to be compatible with extract. This study shows the importance of using instrumental analytical techniques in the early stages of development of herbal medicines to ensure the effectiveness, safety and quality of the final product. The FTIR method, it is proven that FTIR as fast screening tools to check compatibility in early stages of a pre-formulation process. This study also demonstrates the importance of using instrumental techniques in the early stages of development of herbal medicine, selecting excipients that can optimize the activity of Q. infectoria galls extract. Thus, this holds great promise for future research for the formulation of potent antifungal drug for the present plant.

Keywords: Quercus infectoria galls, Excipients, Analytical techniques, Medicinal plants, Compatibility study, Pre-formulation, FT-IR spectral analysis.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More