WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COLORIMETRIC DETERMINATION OF AMLODIPINE BESYLATE AND TAMSULOSIN HYDROCHLORIDE

Ruba N. Shdeed and Imad Shdeed

ABSTRACT

This study presents new spectrophotometric and spectrofluorimetric methods for the estimation of amlodipine besylate and tamsulosin hydrochloride in bulk and in pharmaceutical formulations. The methods depend on the coupling reaction between 4-chloro-7- nitrobenzofurazan [4-chloro-7-nitro-2,1,3-benzoxadiazole] (NBD-Cl) with amlodipine besylate and tamsulosin hydrochloride, respectively, resulting in stable colored products which can be measured spectrophotometrically and spectrofluorimetrically. For amlodipine besylate, its determination was successful by measuring the spectrophotometric absorbance, first derivative and second derivative amplitudes at 471 nm, 500.6 nm, and 495/510 nm, respectively; while the relative fluorescence intensity and its first derivative amplitudes at 533 nm and 502 nm, respectively, was used to determine amlodipine besylate. On the other hand, only spectrophotometric techniques were successful in estimating tamsulosin hydrochloride using the amplitudes of the absorbance, first derivative and second derivative at 513 nm, 512.2 nm and 507.6 nm, respectively. The described methods are simple, sensitive, selective and inexpensive and can be used in quality control analysis.

Keywords: Amlodipine besylate; Tamsulosin Hydrochloride; NBD-Cl; Spectrophotometry; Spectrofluorimetry.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More