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Abstract

IMIPENEM RESISTANCE AMONG GRAM NEGATIVE BACILLI FROM GREAT KWA RIVER, NIGERIA

Archibong C. P.* and and Andy I. E.

ABSTRACT

Emergence of antibiotics resistance bacteria is a persistent global problem affecting public health. The occurrence and widespread resistance to carbapenems among environmental bacterial isolates can constitute a major threat to chemotherapy. This investigation was carried out to assess the antibiotics susceptibility profile of imipenem resistant bacterial isolates from Great Kwa river located in Calabar, Nigeria. From different sites of the Great Kwa River, a total of 89 bacterial isolates were screened for imipenem resistance and susceptibility to 13 antibiotics. Out of the 89 isolates, 20(27.37%) were imipenem resistant, 22(23.16%) showed intermediate resistance while 47(49.47%) were susceptible to imipenem. The resistant and intermediate resistant isolates were of the following genera: Serratia spp (29%), Plesiomonas spp (17%), Aeromonas spp (14%), Acintebacter spp (2%), Providencia spp (2%), Citrobacter spp (5%), Klebsiella spp (5%), Escherichia spp (5%), Proteus spp (11%), Salomnella spp (5%). Among the resistant and intermediate resistant isolates, the percentages that were resistant to the 13 antibiotics were: Orfloxacin (57%), Pefloxacin (21%), Gentamycin (24%), Augmentin (48%), Ampicillin (24%), Ciprofloxacin (14%), Streptomycin (12%), Chloramphenicol (29%), Septrin (33%), Sulfamethoxazole-trimethoprim (29%), Aztreonam (64%), Ceftazidime (76%) and Cefuroxime (38%). Imipenem resistant bacteria are emerging globally at a rapid rate. The resistance can be transferred to human commensals and pathogens and can constitute a threat to an effective therapy using imipenem.

Keywords: Emergence of antibiotics resistance effective therapy using imipenem.


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