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Abstract

RED PIGMENT EXTRACT OF SERRATIA MARCESCENS INHIBITS CELL PROLIFERATION AT THE SCRATCH OF METASTATIC PROSTATE CANCER CELL LINES DU145 AND PC3.

Maithili A. Athavale*, Gayatri A. More, Smera Satish and Sangeeta A. Srivastava

ABSTRACT

Purpose: The aim of the study was to evaluate the effect of Red Pigment Extract (RPE) of Serratia marcescens on cell proliferation at scratch for two prostate cancer cell lines DU145 and PC3. Methods: The effect of RPE of Serratia marcescens on DU145 and PC3 in scratch assay was checked at inhibitory concentration-5(IC5) at periodic time intervals namely 0, 8, 24, 30 and 48hrs for DU145 and PC3 respectively. In case of PC3 time interval was extended further to 54hrs.The width of scratch was measured in μm at each time point by “IS Capture” software. Results: Our results indicated that RPE has a strong effect on cell proliferation at the scratch for both DU145 and PC3 exhibiting % inhibition of 97.5% and 60.3% at the end of 48 and 54hrs respectively. Percentage inhibition of RPE was found to be significantly different (p<0.001) compared to Cisplatin and Sunitinib. Conclusion: Findings of our study indicate that RPE of Serratia marcescens has a strong potential to inhibit cell proliferation at scratch of metastatic prostate cancer cell lines DU145 and PC3.

Keywords: Red Pigment Extract (RPE), Serratia marcescens, scratch assay, PC3 and DU145.


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