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Abstract

ZINGIBER METHANOLIC EXTRACT (ZME) OF DRY GINGER POWDER MITIGATES POTASSIUM DICHROMATENEUROTOXICITY IN RAT BRAIN

Sahar M. Mahmoud* and Ahmed E. Abdel Moneim

ABSTRACT

The wide environmental distribution of Cr (VI) has increased the interest of its possible toxicity. Chromium (VI) the most toxic form, has been demonstrated to induce nephrotoxicity associated with oxidative stress in humans and animals. The present study was undertaken to evaluate the effect of Zingiber methanolic extract (ZME) on brain of normal as well as potassium dichromate (PDC) intoxicated adult male albino rats. Adult male rats were divided into seven groups: (I) served as control, (II) (KCr), received a single i.p. injection of PDC (15mg\ Kg body weight), (III) (ZME) Rats were administered Zingiber methanolic extract (ZME) dissolved in tween 20 (10%) (200mg\ Kgbody weight), (IV) rats were treated with ZME and PDC. Administration of ZME either alone or to K2Cr2O7-treated rats revealed changes in the investigated biochemical parameters (malonaldehyde (MDA), catalase (CAT) and superoxide dismutase (SOD), glutathion (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GSt) and nitric oxide (NO), in brains tissue homogenate of all groups. Other parameters namely; tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) contents were also recorded as a correlation between oxidative stress as well as proinflammatory cytokines. Histopathological investigations revealed that PDC injection caused neuron necrosis in cerebral cortex, hippocampus and striatum associated with neuronophagia. Meanwhile, ZME administration to KCr –treated rats was found to diminish necrosis observed in brain of KCr-treated rats and increase cellular density. It could be concluded from this study that ZME of dry ginger indicated its antioxidant anti-inflammatory property, as it seemed to affect brain oxidant-antioxidant status and ameliorate PDC neurotoxicity.

Keywords: Ginger extract, Potassium dichromate, Neurotoxicity, Oxidative Stress, Necrosis.


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