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Abstract

INDICATION OF PROGNOSIS AND HEALTH RELATED QUALITY OF LIFE IN PATIENTS ON DOTS THERAPY AT TB UNIT IN NORTH KERALA

Dr. N. Premkumar, Dr. Usha Karunakaran, Arun Kumar A., Roshen Jacob Sam*

ABSTRACT

Direct Observation Therapy Short Term (DOTS) is a medication course initiated by WHO for treating tuberculosis across the globe. Hence it is a six month course, our study is focused on the effectiveness of the treatment in various patients who are receiving the medication at least for 2 months. METHOD A multicenter study was carried out over a period of six months at DOTs center of tertiary hospital and nearby Govt. Taluk Hospital. Patients who are taking the DOTs regimen were included for the study. Sputum conversion, weight gain, adverse events and treatment discomfort are taken as the main criteria to evaluate the quality of life of patients in this study. RESULT Total 55 patients were enrolled out of which 44 (74.5%) are males and 11 (25.5%) were females. The maximum number of cases was seen in the age group of 41 – 50 years, about 11 (20 %) (7.3%) and the least number of patients were observed in the age category of 0 – 10 (1.8%) about 1 patient. Out of 55 patients, 44 (80%) of them shows smear negative as result and 11 (20%) shows smear positive and 36 (65.5%) of them has gained weight, 14 patients (25.5%) maintained their weight on DOTs therapy. 55 patients were ruled out and 14 (25.5%) were able to complete the course and shows complete sputum conversion and increased weigh hence improving overall quality of the life of the patients. CONCLUSION The study shows that men are more prevalence than women and also observed that uncomplicated side effect like skin rashes, vomiting and itching are seen in some patients. Rifampicin induced urine discoloration is the most predominant Adverse event during DOTs therapy. Overall health related quality of life of patients on DOTs therapy increases after completing the treatment course. While considering the whole findings we attain a conclusion that with proper follow up we can improve the quality of life and patient compliance during dots therapy.

Keywords: Tuberculosis, DOTs therapy, HRQOL, Sputum conversion, Weight gain, Adverse drug reaction.


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