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Abstract

INVESTIGATION OF PHYTOCHEMICALS AND ANTIOXIDANT POTENTIAL OF LEAF EXTRACT OF Sesbania grandiflora L. Pers

Priyanka Das* and Jyoti Harindran

ABSTRACT

Nowadays there is resurgence of interest in the potential health benefits
of natural remedies like medicinal plants and their extracts. The
presence of antioxidants such as phenolics and flavonoids in plants
may provide protection against a number of diseases and have attracted
much interest because of their ability to scavenge free radicals.
Medicinal plants are therefore investigated for their antioxidant
properties, and their demand is increasing worldwide. The present
study was aimed to screen the phytochemicals as well as to evaluate
the antioxidant potential of ethanolic extract of Sesbania grandiflora L.
Pers leaves. Finely powdered leaves of S.grandiflora (white variety)
were macerated using 95% ethanol. The ethanol extract was subjected
to phytochemical screening and estimation of total phenol and flavonoid contents. In vitro
antioxidant assays such as DPPH, Nitric oxide and Hydrogen peroxide radical scavenging
assays were performed to determine the free radical scavenging activity. Qualitative
phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids,
phenolics, tannins, steroids, anthraquinone glycosides, carbohydrates and proteins. Total
flavonoid and phenol contents in 10 mg of extract were found to be 0.956 mg and 0.136 mg
of standard quercetin and gallic acid respectively. The extract showed satisfactory scavenging
in all the antioxidant assays with potent activity against hydrogen peroxide radical with an
IC50 of 39.25 μg /ml. Antioxidant activity of the ethanol extract of S.grandiflora can be
attributed to the presence of flavonoid and phenolic contents.

Keywords: Free radicals, Reactive oxygen species, Phenolics, Flavonoids.


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