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Abstract

IMPLICATIONS OF PHYSICAL ACTIVITY ON THE MARKERS OF RENAL DAMAGE AMONG TYPE 2 DIABETIC SUBJECTS

R. Suja Pandian*

ABSTRACT

Diabetes mellitus is the fast spreading epidemic of the 21st century and mortality rate is high among the physically inactive middle and old aged people. Diabetic Nephropathy is the leading cause of End Stage Renal Disease and affects approximately 40% of Type 2 Diabetic patients and most of the patients entering dialysis are diabetic. In the present study the impact of physical activity on the markers of renal damage among young, middle and older aged diabetic subjects, living in semi urban area Thanjavur town, Tamil Nadu has been investigated. For the present study, the male subjects of 35-45, 46-55 and 56-65 years were selected. The activity of analyzed biomarkers of renal damage was found to be significantly elevated in elderly diabetic persons when compared to the physically active diabetic subjects. Increased blood urea production in diabetes may be accounted for by enhanced catabolism of both liver and plasma proteins. Uric acid is a strong and an independent risk factor for diabetes. Hyperglycemia induced elevated levels of plasma urea and creatinine are considered as significant markers of renal dysfunction. However the present study indicated that the Groups which are active physically and regularly doing exercise particularly walking has reduced renal damage markers nearly to the normal Group. There is a positive and significant correlation obtained between lifestyle modified people and diabetic control.

Keywords: diabetes, liver enzymes, physical activity, walking.


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