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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING TABLET OF ORLISTAT

Vinay Koli, Hiral Bariya, Hitesh Jain* and D. B. Meshram

ABSTRACT

Objective: The objective of present work is to formulate the gastro retentive floating tablets containing Orlistat. Experimental work: The floating tablets of orlistat were prepared by direct compression methodusing Polyox WSR 303 sustained release polymer and Sodium bicarbonate as a floating effervescent agent. Optimization was done with 3² factorial design by taking concentration of polyox WSR 303 and sodium bicarbonate as independent variables and floating lag time and % CDR as dependent factors. The optimized batch of floating tablet was subjected for the short term stability study at 40±2ºc with RH of 75% for a period of one month. The prepared formulations were evaluated for hardness, friability, weight variation, swelling index, floating lag time, floating time and % drug release. Result and discussions: All the physiochemical properties of prepared floating tablets were found to be in acceptable range. The optimum concentration of polyox WSR 303 and Sodium bicarbonate were required to formulate floating tablet to increase gastric retention time. From the formulated factorial batches S3, batch containing 22.5% polyox WSR 303 and 7.5% sodium bicarbonate showed lowest lag time of 25.22±0.41 sec and highest % drug release at 12 hours of 98.53%. Conclusion: From the result obtained it was concluded that optimized formulation containing polyox WSR 303 and Sodium bicarbonate shows better swelling properties with desired drug release properties and floating behaviour. Hence polyox WSR 303 is a potential polymer candidate for formulation of sustained release floating effervescent tablet.

Keywords: Floating drug delivery system, obesity, polyox WSR 303.


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