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Abstract

DEVELOPMENT AND CHARACTERIZATION OF OSMOTIC DRUG DELIVERY SYSTEM OF MODEL DRUG

Rajnandni S. Suroshe*, R. B. Wakade, Wrushali A. Panchale, Anjali D. Sakhare, Rounak R. Rathod and Paras B. Pophalkar

ABSTRACT

Aim of present study is to develop osmotic controlled drug delivery of drug vildagliptin for controlling the release pattern of drug to achieve better efficacy. The clinical utility of GLP-1 is limited by its short halflife (2-3 hrs). GLP-1 is rapidly degraded by the proteolytic enzyme DPP-IV. To enhance GLP-1 activity, inhibition of the DPP-IV enzyme is emerging as a novel therapeutic approach in the treatment of diabetes. Osmotically controlled drug delivery systems (OCDDS) is one of the most promising drug delivery technology that use osmotic pressure as a driving force for controlled delivery of active agents. Osmotic tablet is prepared by core tablet and coating solution. core tablet consist of polymer (MCC), osmogen (KCl and NaCl) and other excipients. The tablets were coated by spray coating solution which is the mixture of Acetone and methanol in the ratio of 8:2 with cellulose acetate, pore forming agent is PEG 4000, and plasticizer is PEG 400. Different kinetic treatments were applied to interpret the release of Vildagliptin from different osmotic tablet. The r2 value of formulation batch F2C4 has highest value that was r2= 0.9720 than other of zero order kinetic of batches hence F2C4 batch of osmotic tablet was best and optimized formulation. Hence revealed that optimized formulation followed zero order drug release kinetics.

Keywords: Vildagliptin, Osmotically controlled drug delivery systems, zero order.


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