WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

A QUANTITATIVE DETERMINATION OF CHLOROACETIC ACIDS IN CETIRIZINE HYDROCHLORIDE API BY GAS CHROMATOGRAPHY

Rajendra Phadke*, Swapnil Patil and Dr. Amit Gosar

ABSTRACT

A gas chromatographic procedure has been developed for the determination of chloroacetic acid in cetirizine hydrochloride API. Due to the high polar acidic in nature of chloroacetic acid, compound was not eluted properly in Gas chromatograph column. Therefore derivatizating technique need, Compound was derivatised using reagent N, OBist (trimethylsilyl) trifluoroacetamide (BSTFA) in presence of methyl tert-butyl ether solvent prior to their analysis via gas chromatogram coupled with a flame ionization detector (GC-FID). The derivatised chloroacetic acid was well separated on HP-5 column, 30 m, 0.32 mm ID, 0.25m film thickness. The oven program was 40°C initial temper ature hold time 8.0 minute, then 20C ramp per min upto 200C then hold to 4.0 minute. This analytical method was validated as per international conference on harmonization guideline for parameter specificity, linear, accuracy, precision and limit of detection and limit of quantitation. The obtained recovery of chloroacetic acid was found to be 90% to 110% and detection and quantitation limit was 0.0081% and 0.025% with respective to cetirizine hydrochloride API. The linearity was ranging from 0.08 to 0.23% with respective to cetirizine hydrochloride API and the observed correlation coefficients was 0.9990. The repeatability was evaluated against limit concentration and at LOQ level concentration, which were obtained as 1.82% and 2.05%.

Keywords: Cetirizine hydrochloride API, Gas chromatograph, Chloroacetic acid, Derivative, Method development, Validation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More