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Abstract

FORMULATION AND EVALUATION OF METFORMIN TRANSCUTANEOUS PATCHES

*Sandhya Mandadi and M. Venkataswamy

ABSTRACT

The aim of the work was to develop a sustained release transcutaneous patch of metformin hydrochloride using natural and synthetic polymers like HPMC and PEG. Transcutaneous drug delivery can be efficiently used for the drugs which cause severe gastritis and undergo rapid first pass effect; hence the transcutaneous patches of metformin hydrochloride were prepared by using combination of PEG and HPMC along with GLYCERINE as a plasticizer. The prepared formulations were evaluated for thickness, weight variation, drug content, folding endurance, moisture content, in vitro permeation studies. The patches showed best tensile strength, folding endurance. In vitro dissolution test was carried for 24 hours and formulation F7 showed 95.89% drug release at the end of 24 hours. Release kinetics studies revealed that the drug release from formulation F7 followed zero order kinetics with release exponent value n=0.997, which shows that release pattern of patches follows Non - fiction diffusion mechanism. It was observed that the system with PEG: HPMC in the ratio 75:25 along with plasticizer was very promising in controlling release of Metformin via transcutaneous drug delivery system.

Keywords: Formulation, Evaluation, Metformin, Transcutaneous, Patches.


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