WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

THE SYNERGISTIC EFFECT OF ETHANOL LEAF EXTRACT OF ANNONA MURICATA AND ARTOCARPUS HETEROPHYLLUS ON HIGH FAT DIET INDUCED HYPERLIPIDAEMIA IN WISTAR ALBINO RATS

C. L. Onuah*, F. C. Anacletus, A. A. Uwakwe and P. N. Okoroh

ABSTRACT

The antihyperlipidaemic and antihypertensive effects of ethanol leaf extract of Annona muricata, Artocarpus heterophyllus and combined ethanol leaf extract of Annona muricata and Artocarpus heterophyllus on male wistar albino rats were studied. Forty eight (48) rats were given high fat diet (HFD) to induce hyperlipidaemia. The rats were treated with 200mg/kg body weight of A. muricata and A. heterophyllus, 100 and 200mg/kg body weight of combined ethanol leaf extract of A. muricata and A. heterophyllus. Ethanol leaf extract of A. muricata and A. heterophyllus had a positive effect on the total cholesterol, triglyceride, and high density lipoprotein level of the diabetic rats. The effects of the combined ethanol leaf extract on the heart tissue oxidative stress markers of the rats were also studied. A decrease which is statistically significant at p<0.05 was observed in the malondialdehyde level (0.50±0.07 μmol/ml) of the research animals. The result showed that ethanol leaf extract of A. muricata and A. heterophyllus with their combined extract had antihyperlipidaemic effect on high fat diet-induced hyperlipidaemia in wistar albino rats.

Keywords: Hyperlipedeamia, oxidative stress, antihyperlipidaemia, blood pressure, High fat diet, wistar albino rats.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More