ANTIHYPERGLYCEMIC ACTIVITY STUDIES WITH MALVA VERTICILLATA LEAVES
Farhana Akter and Mohammed Rahmatullah*
ABSTRACT
Background: Malva verticillata, also known as Chinese mallow and
cluster mallow is considered a medicinal herb by traditional medicinal
practitioners in Bangladesh The objective of the present study was to
evaluate the antihyperglycemic efficacy of methanol extracts of the
leaves of the plant (MEMV). Methods: Oral glucose tolerance test
(OGTT) was done to evaluate antihyperglycemic efficacy. Results: In
oral glucose tolerance tests, MEMV dose-dependently and
significantly reduced blood glucose levels in glucose-loaded mice. At
doses of 50, 100, 200 and 400 mg per kg body weight, MEMV lowered
blood glucose levels by 20.4, 32.0, 37.2, and 46.6%, respectively,
compared to control animals. By comparison, a standard
antihyperglycemic drug, glibenclamide reduced blood glucose levels by 45.3% at a dose of
10 mg per kg. Conclusion: The leaves can be an effective means for lowering blood glucose
in persons with elevated blood glucose levels like people with diabetes.
Keywords: Antihyperglycemic, Malva verticillata, OGTT, diabetes.
[Full Text Article]