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Abstract

GASTRIC EMPTYING AND PSYCHOPHARMACOLOGICAL EFFECTS OF NABAYAS LOUHA ON ANIMALS

Ashfaqur Rahman*, Tamzid Zaman, Rajib Das, Md. Mahidul Islam, M. S. K. Choudhuri and Apurba Sarker Apu

ABSTRACT

Objective: The research work was carried out to characterize the gastric emptying and psychopharmacological effects of ayurvedic iron preparation ―Nabayas Louha‖ in swiss albino mice. Methods: Nabayas Louha was administered by oral route to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with normal saline water. Nabayas Louha was used at a dose of 100 mg/kg to examine its gastric emptying effects. To investigate the psychopharmacological effects of Nabayas Louha climbing out, staircase and forced induce swim test had been carried out where 100, 200 and 400 mg/kg body weight dose (by mouth) was used for climbing out test and 100 mg/kg body weight dose (by mouth) was used for staircase and forced induce swim test. Results: Oral administration of Nabayas Louha was found to increase the % of gastrointestinal emptying and one of the 2nd hour results was a significant (p<0.05). In the forced swimming test two results were noticeable (p<0.099) and one result was very significant (p<0.01) for depressant effect of Nabayas Louha. Conclusions: It can be said that Nabayas Louha has significant gastric emptying effects and may have depressant activities but probably don’t have any effect like anxiolytic activity. To establish these effect further studies may be required.

Keywords: Nabayas Louha, Gastric emptying, Psychopharmacological, Anxiolytic, Depressant, Swiss albino mice.


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