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Abstract

DESIGN AND DEVELOPMENT OF NANOGELS CONTAINING CARBAPOL AS POLYMER AND HYDROALCOHOLIC EXTRACT OF PTEROCARPUS MARSUPIUM AS HERBAL MEDICAMENT

Pranuti D. Patil*, Susmita B. Patil, Prasanna S. Patil and Dr. Vijay R. Salunkhe

ABSTRACT

The aim of present work is to design Pterocarpus marsupium loaded nonogel for anti-inflammatory and to evaluate the nanogels by in vitro studies. Nanogels are swollen nanosized networks composed of hydrophilic or amphiphilic polymer chains that have attracted considerable attention as multifunctional polymer-based drug delivery systems. The gels were prepared by using extract of pterocarpus marsupium, carbapol 940, EDTA, ethanol, propylene glycol, methyl paraben, propyl paraben, triethalonamine and required quantity of water. The gels were prepared by nanogels from polymer precursors method, in this method extract was dissolved in propylene glycol and ethanol, in another phase carbopol was mixed in water and forms jelly like mixture, both mixture were mixed together and homogenized in high speed homogenizer: homogenize it up to formation of gel consistency: after homogenizing mixture was sonicated by using ultra sonicator for 20min. Evalution tests were performed by using various parameter prepared nanogel was stable, particle size was found to be in nano range. Prepared nanogels were stable, palatable, and acceptable and are compatible to consumers.

Keywords: The aim of present work Pterocarpus marsupium compatible to consumers.


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