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Abstract

A CLINICAL CASE STUDY OF ALOPECIA AREATA TREATED WITH TRADITIONAL SIDDHA FORMULATIONS SEENTHIL CHOORANAM AND MALAIVEMBHATHI THAILAM

J. Nisha*, N. J. Muthu Kumar and V. Banumathi

ABSTRACT

Alopecia areata (AA) also known as Puzhuvettu in tamil is an autoimmune disorder which is characterized by disease involving nonscarring patchy hair loss determined mainly due to underlying inflammation. This disease may affects hair on the scalp and/or other parts of the body. The AA occurs in people of all ages and affects 1– 2% of humans. Skin biopsies of AA affected skin show a lymphocytic infiltrate in and around the bulb or the lower part of the hair follicle in anagen (hair growth) phase. A breakdown of immune privilege of the hair follicle is thought to be an important driver of alopecia areata. Management of AA can be challenging, and although multiple treatment modalities have been explored, no therapy is currently FDAapproved. The decision on the type of treatment depends on the type of hair loss, extent of changes, general health status, the patient's age, and his/her motivation. Treatment methods should be chosen individually for each patient. Immunosuppressant drugs such as cyclosporine, methotrexate and azathioprine along with corticosteroids are being currently used for clinical management of AA, whereas these drugs offers numerous side effect upon long term usage included acne, striae, cushingoid face, truncal obesity, easy bruising, osteoporosis, weight gain. Further usage of all immunosuppressant drugs carry the serious risk of infection. Hence exploration of drug from alternate complimentary source with fewer side effects and with improved efficacy becomes highly essential and need of the hour for clinical management of AA. Present investigation aimed at clinical evaluation of the siddha formulations Seenthilchooranam (SC) for internal and Malaivembhathithailam (MT) for external therapy for management of AA. Outcome of the study reveals that treatment with SC and MT has shown significant improvement in sixty days of treatment evident with high rate of hair proliferation. Further there is no significant changes were observed in any of the hematology, serology and urine parameters observed during the study phase. It was concluded from the data’s obtained from the present case study that siddha formulations possess excellent activity in treating AA and further study has to be carried out on its clinical implication in larger population in both the genders and also to study the molecular mechanism underlying the action of the drugs in clinical management of AA.

Keywords: Alopecia Areata, Immunosuppressant, Corticosteroids, Siddha Formulations, Seenthilchooranam (SC), Malaivembhathithailam.


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