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Abstract

ANALYTICAL STANDARDIZATION OF SHATPALA GANDHAKA CHURNA

Hema T.*, Venkata Subbaiah K. and Sridurga Ch.

ABSTRACT

Rasa Shastra is a specialized branch of Ayurveda which mainly deals with the pharmaceutics of unique and potent preparations. Shatpala Gandhaka churna is an important Rasa Oushadi mentioned in Vaidya Chintamani- Kushtha roga prakaranam The chief ingredients of the formulation are Shuddha Gandhaka, Shuddha Bhallataka, Shuddha Chitrakamula twak, Triphala, Vidanga, Trikatu, Trijataka, Chanaka, and Jeeraka. The main Pharmaceutical procedures adopted for preparation of Shatpala Gandhaka Churna are Shodhana and Churna nirmana. Analytical study plays an important role in the standardization of the drugs. To assess the toxicity, safety and to understand the structural and chemical composition, it was tested through various modern analytical parameters like X-ray diffraction (XRD), Scanning electron microscopy (SEM), Particle size analysis (PSA), Zeta Potential (ZP), UVSpectroscopy, Fourier transform Infra-Red spectroscopy (FTIR) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES). XRD of Shatpala Gandhaka churna shows major peaks of Sulphur(S8). SEM micrograph showed distribution of particles in Shatpala Gandhaka Churna as clusters of Spherical and Elliptical shaped particles; Particle size was found to be 10.9 nm and Zeta Potential is -40.9 mV. UV- Spectrum of Shatpala Gandhaka churna showed maximum absorption at 226 nm and 270 nm. FT-IR analysis showed 10 peaks between the wavelengths 3415.99-406.35cm-1 and ICP–OES analysis revealed Sulphur as main constituent in 14376.50 ppm.

Keywords: Shatpala Gandhaka Churna, Modern Analytical parameters, Safety, Toxicity, Standardization.


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